Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 9/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.36 |
| ▸ | DUT | P33316 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30550878 | 0.88 | TNF (0.42) | TNFHDAC3HDAC1HDAC6PSMB1 | |
| SCHEMBL25319011 | 0.81 | TNF (0.37) | TNFHDAC3HDAC1HDAC6PSMB1 | |
| SCHEMBL25320868 | 0.79 | TNF (0.49) | TNFHDAC3HDAC1HDAC6PSMB1 | |
| SCHEMBL25899461 | 0.78 | TNF (0.56) | TNFHDAC3HDAC1HDAC6PSMB1 | |
| SCHEMBL25321729 | 0.77 | TNF (0.43) | TNFHDAC3HDAC1HDAC6PSMB1 | |
| SCHEMBL25324896 | 0.76 | PSMB1 (0.41) | TNFHDAC3HDAC1HDAC6PSMB1 | |
| SCHEMBL25320458 | 0.75 | PTPN1 (0.38) | TNFPSMB1PSMB5 | |
| SCHEMBL25320463 | 0.75 | PTPN1 (0.38) | TNFPSMB1PSMB5 | |
| SCHEMBL25901429 | 0.73 | HDAC3 (0.36) | TNFHDAC3HDAC1HDAC6PSMB1 | |
| SCHEMBL25899466 | 0.73 | TNF (0.39) | TNFHDAC3HDAC1HDAC6PSMB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230365529-A1 | PARP7 INHIBITORS | GILEAD SCIENCES, INC. | 2023-11-16 | — | — | US | disclosed |
| WO-2023147418-A1 | PARP7 INHIBITORS | GILEAD SCIENCES, INC. (US) | 2023-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230365529-A1 | PARP7 INHIBITORS | PARP1, PARP11, PARP2 | TNF 4831/4885HDAC3 83/4885HDAC1 106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.