Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 12/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.44 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26788218 | 0.88 | TNF (0.60) | TNFHDAC3HDAC1HDAC6PSMB1 | |
| SCHEMBL25320868 | 0.84 | TNF (0.49) | TNFHDAC3HDAC1HDAC6PSMB1 | |
| SCHEMBL25321729 | 0.82 | TNF (0.43) | TNFHDAC3HDAC1HDAC6PSMB1 | |
| SCHEMBL25324896 | 0.78 | PSMB1 (0.41) | TNFHDAC3HDAC1HDAC6PSMB1 | |
| SCHEMBL25318628 | 0.78 | TNF (0.41) | TNFHDAC3HDAC1HDAC6PSMB1 | |
| SCHEMBL30550878 | 0.77 | TNF (0.42) | TNFHDAC3HDAC1HDAC6PSMB1 | |
| SCHEMBL25899466 | 0.76 | TNF (0.39) | TNFHDAC3HDAC1HDAC6PSMB1 | |
| SCHEMBL25903514 | 0.75 | TNF (0.37) | TNFHDAC3HDAC1HDAC6PSMB1 | |
| SCHEMBL30550902 | 0.74 | TNF (0.37) | TNFHDAC3HDAC1HDAC6PSMB1 | |
| SCHEMBL25320560 | 0.74 | TNF (0.37) | TNFHDAC3HDAC1HDAC6PSMB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023147418-A1 | PARP7 INHIBITORS | GILEAD SCIENCES, INC. (US) | 2023-08-03 | — | — | WO | disclosed |