Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25319291 | 1.00 | NPC1 (0.53) | NPC1POLBRAB9ADYRK1AGSK3B | |
| SCHEMBL31578482 | 1.00 | NPC1 (0.53) | NPC1POLBRAB9ADYRK1AGSK3B | |
| SCHEMBL30551480 | 1.00 | NPC1 (0.53) | NPC1POLBRAB9ADYRK1AGSK3B | |
| SCHEMBL25323632 | 0.89 | GSK3B (0.43) | NPC1POLBRAB9AGSK3BALDH1A1 | |
| SCHEMBL31578433 | 0.89 | GSK3B (0.43) | NPC1POLBRAB9AGSK3BALDH1A1 | |
| SCHEMBL25323626 | 0.89 | GSK3B (0.43) | NPC1POLBRAB9AGSK3BALDH1A1 | |
| SCHEMBL31578497 | 0.81 | MAOA (0.43) | NPC1RAB9AGSK3BALDH1A1TSHR | |
| SCHEMBL25320632 | 0.81 | MAOA (0.43) | NPC1RAB9AGSK3BALDH1A1TSHR | |
| SCHEMBL25320626 | 0.81 | MAOA (0.43) | NPC1RAB9AGSK3BALDH1A1TSHR | |
| SCHEMBL25322498 | 0.75 | CYP1A2 (0.40) | CYP1A2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4469455-A1 | COMPOUNDS AND METHODS OF USE | Tango Therapeutics, Inc. (US) | 2024-12-04 | — | — | EP | disclosed |
| WO-2023146990-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |