Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.58 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.58 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.58 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.58 |
| ▸ | TNF | P01375 | 4/20 | 0.58 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.58 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.58 |
| ▸ | HCK | P08631 | 2/20 | 0.58 |
| ▸ | ABL1 | P00519 | 2/20 | 0.58 |
| ▸ | RAF1 | P04049 | 2/20 | 0.58 |
| ▸ | LYN | P07948 | 2/20 | 0.58 |
| ▸ | SRC | P12931 | 2/20 | 0.58 |
| ▸ | CIT | O14578 | 1/20 | 0.58 |
| ▸ | MUSK | O15146 | 1/20 | 0.58 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.58 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.58 |
| ▸ | STK10 | O94804 | 1/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.58 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7964926 | 0.85 | MAPK14 (0.78) | MAPK14MAPK12MAPK13MAPK11TNF | |
| SCHEMBL296487 | 0.80 | MAPK14 (0.76) | MAPK14MAPK12MAPK13MAPK11TNF | |
| SCHEMBL20876925 | 0.80 | MAPK14 (0.76) | MAPK14MAPK12MAPK13MAPK11TNF | |
| SCHEMBL29593381 | 0.80 | MAPK14 (0.76) | MAPK14MAPK12MAPK13MAPK11TNF | |
| SCHEMBL7963067 | 0.78 | MAPK14 (0.80) | MAPK14MAPK12MAPK13MAPK11TNF | |
| SCHEMBL29593331 | 0.78 | MAPK14 (0.77) | MAPK14MAPK12MAPK13MAPK11TNF | |
| SCHEMBL295153 | 0.78 | MAPK14 (0.77) | MAPK14MAPK12MAPK13MAPK11TNF | |
| SCHEMBL29594073 | 0.75 | MAPK14 (0.77) | MAPK14MAPK12MAPK13MAPK11TNF | |
| SCHEMBL297064 | 0.75 | MAPK14 (0.77) | MAPK14MAPK12MAPK13MAPK11TNF | |
| SCHEMBL30335874 | 0.75 | MAPK14 (0.65) | MAPK14MAPK12MAPK13MAPK11TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170204192-A1 | HUMAN SERUM ALBUMIN LINKERS AND CONJUGATES THEREOF | MERRIMACK PHARMACEUTICALS, INC. | 2017-07-20 | — | — | US | disclosed |
| US-20150191545-A1 | HUMAN SERUM ALBUMIN LINKERS AND CONJUGATES THEREOF | MERRIMACK PHARMACEUTICALS, INC. | 2015-07-09 | — | — | US | disclosed |
| EP-2860260-A1 | Human serum albumin linkers and conjugates thereof | Merrimack Pharmaceuticals, Inc. (US) | 2015-04-15 | — | — | EP | disclosed |
| US-8927694-B2 | Human serum albumin linkers and conjugates thereof | MERRIMACK PHARMACEUTICALS, INC. (US) | 2015-01-06 | — | — | US | disclosed |
| EP-2288715-B1 | HUMAN SERUM ALBUMIN LINKERS AND CONJUGATES THEREOF | MERRIMACK PHARMACEUTICALS INC (US) | 2014-09-24 | — | — | EP | disclosed |
| US-20120003221-A1 | HUMAN SERUM ALBUMIN LINKERS AND CONJUGATES THEREOF | MERRIMACK PHARMACEUTICALS, INC. (US) | 2012-01-05 | — | — | US | disclosed |
| US-20110059076-A1 | HUMAN SERUM ALBUMIN LINKERS AND CONJUGATES THEREOF | MERRIMACK PHARMACEUTICALS, INC. | 2011-03-10 | — | — | US | disclosed |
| WO-2010059315-A1 | HUMAN SERUM ALBUMIN LINKERS AND CONJUGATES THEREOF | MERRIMACK PHARMACEUTICALS, INC. (US) | 2010-05-27 | — | — | WO | disclosed |
| WO-2009124056-A2 | ALPHA-FETOPROTEIN FOR TREATING DISEASE | MERRIMACK PHARMACEUTICALS, INC. (US) | 2009-10-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120003221-A1 | HUMAN SERUM ALBUMIN LINKERS AND CONJUGATES THEREOF | ALB, HDGF, VCAM1 | MAPK14 2506/4885MAPK12 2818/4885MAPK13 2221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.