Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 11/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25321367 | 1.00 | AAK1 (0.41) | AAK1FPR2PSMB1PSMB5ACACB | |
| SCHEMBL30550799 | 0.84 | PSMB1 (0.42) | AAK1PSMB1PSMB5HDAC3HDAC1 | |
| SCHEMBL25321479 | 0.84 | PSMB1 (0.42) | AAK1PSMB1PSMB5HDAC3HDAC1 | |
| SCHEMBL25321476 | 0.84 | PSMB1 (0.42) | AAK1PSMB1PSMB5HDAC3HDAC1 | |
| SCHEMBL25898525 | 0.78 | HTR2C (0.40) | PSMB1PSMB5TIPARPHDAC3HDAC1 | |
| SCHEMBL30550679 | 0.76 | ACACB (0.33) | ACACBTIPARP | |
| SCHEMBL25323968 | 0.76 | ACACB (0.33) | ACACBTIPARP | |
| SCHEMBL25320458 | 0.73 | PTPN1 (0.38) | AAK1PSMB1PSMB5 | |
| SCHEMBL25320463 | 0.73 | PTPN1 (0.38) | AAK1PSMB1PSMB5 | |
| SCHEMBL25899466 | 0.73 | TNF (0.39) | AAK1PSMB1PSMB5SCN9AHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12459922-B2 | PARP7 inhibitors | GILEAD SCIENCES, INC. (US) | 2025-11-04 | — | — | US | disclosed |
| EP-4469448-A1 | PARP7 INHIBITORS | GILEAD SCIENCES, INC. (US) | 2024-12-04 | — | — | EP | disclosed |
| US-20230365529-A1 | PARP7 INHIBITORS | GILEAD SCIENCES, INC. | 2023-11-16 | — | — | US | disclosed |
| US-20230365529-A1 | PARP7 INHIBITORS | GILEAD SCIENCES, INC. | 2023-11-16 | — | — | US | disclosed |
| WO-2023147418-A1 | PARP7 INHIBITORS | GILEAD SCIENCES, INC. (US) | 2023-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12459922-B2 | PARP7 inhibitors | PARP1, PARP11, PARP2 | AAK1 2312/4885FPR2 4319/4885PSMB1 1952/4885 |
| US-20230365529-A1 | PARP7 INHIBITORS | PARP1, PARP11, PARP2 | AAK1 2312/4885FPR2 4319/4885PSMB1 1952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.