Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 2/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.32 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.32 |
| ▸ | CLK2 | P49760 | 2/20 | 0.32 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25324329 | 1.00 | PIK3CD (0.41) | PIK3CDUSP30PRMT5WDR77BRD4 | |
| SCHEMBL29477676 | 0.88 | PIK3CD (0.46) | PIK3CDPRMT5BRD4CREBBPCDK8 | |
| SCHEMBL30551259 | 0.88 | PIK3CD (0.46) | PIK3CDPRMT5BRD4CREBBPCDK8 | |
| SCHEMBL24365179 | 0.88 | PIK3CD (0.46) | PIK3CDPRMT5BRD4CREBBPCDK8 | |
| SCHEMBL25322160 | 0.88 | PIK3CD (0.46) | PIK3CDPRMT5BRD4CREBBPCDK8 | |
| SCHEMBL29477605 | 0.81 | PIK3CD (0.41) | PIK3CDCDK8RIPK2 | |
| SCHEMBL24365687 | 0.81 | PIK3CD (0.41) | PIK3CDCDK8RIPK2 | |
| SCHEMBL25327111 | 0.80 | USP30 (0.37) | USP30PRMT5WDR77BRD4CREBBP | |
| SCHEMBL30551496 | 0.79 | PIK3CD (0.42) | PIK3CDPRMT5CDK8RIPK2CCNC | |
| SCHEMBL29081206 | 0.75 | NAMPT (0.42) | PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146990-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |