Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 10/20 | 0.53 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | KIF11 | P52732 | 2/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25326433 | 0.87 | RIPK1 (0.50) | RIPK1PDE5APDK1PDK2PDK3 | |
| SCHEMBL30522890 | 0.87 | RIPK1 (0.50) | RIPK1PDE5APDK1PDK2PDK3 | |
| SCHEMBL25325613 | 0.86 | RIPK1 (0.49) | RIPK1PDE5AMAOAMAOBKIF11 | |
| SCHEMBL30522916 | 0.86 | RIPK1 (0.49) | RIPK1PDE5AMAOAMAOBKIF11 | |
| SCHEMBL25325607 | 0.86 | RIPK1 (0.49) | RIPK1PDE5AMAOAMAOBKIF11 | |
| SCHEMBL25327354 | 0.86 | RIPK1 (0.58) | RIPK1PDK1PDK2PDK3PDK4 | |
| SCHEMBL25325898 | 0.86 | RIPK1 (0.44) | RIPK1PDE5APDK1PDK2PDK3 | |
| SCHEMBL25326988 | 0.84 | RIPK1 (0.53) | RIPK1PDK1PDK2PDK3PDK4 | |
| SCHEMBL25325929 | 0.83 | RIPK1 (0.40) | RIPK1PDE5AALOX5MAOAMAOB | |
| SCHEMBL25326719 | 0.81 | RIPK1 (0.44) | RIPK1PDE5APDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146991-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |