Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | HHAT | Q5VTY9 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 5/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25328383 | 1.00 | POLB (0.50) | POLBMEN1TSHRHTTKMT2A | |
| SCHEMBL25324288 | 0.85 | POLB (0.45) | POLBMEN1TSHRHTTKMT2A | |
| SCHEMBL18711396 | 0.85 | POLB (0.61) | POLBMEN1TSHRHTTKMT2A | |
| SCHEMBL4657693 | 0.85 | RIPK1 (0.47) | POLBMEN1KMT2ARIPK1 | |
| SCHEMBL4657697 | 0.85 | RIPK1 (0.47) | POLBMEN1KMT2ARIPK1 | |
| SCHEMBL25327354 | 0.84 | RIPK1 (0.58) | RIPK1 | |
| SCHEMBL25326983 | 0.82 | NR1H2 (0.48) | POLBRIPK1ABCB1 | |
| SCHEMBL25326986 | 0.82 | NR1H2 (0.48) | POLBRIPK1ABCB1 | |
| SCHEMBL25327211 | 0.81 | PRMT5 (0.39) | POLBRIPK1 | |
| SCHEMBL25326948 | 0.79 | RIPK1 (0.42) | POLBOPRM1OPRK1RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146991-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |