Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 10/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 1/20 | 0.39 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4657693 | 1.00 | RIPK1 (0.47) | RIPK1POLBKMT2AALDH1A1RAB9A | |
| SCHEMBL25328385 | 0.85 | POLB (0.50) | RIPK1POLBKMT2AMEN1 | |
| SCHEMBL25328383 | 0.85 | POLB (0.50) | RIPK1POLBKMT2AMEN1 | |
| SCHEMBL18711396 | 0.83 | POLB (0.61) | RIPK1POLBKMT2AMEN1 | |
| SCHEMBL18863621 | 0.83 | RIPK1 (0.64) | RIPK1POLBKMT2AALDH1A1RAB9A | |
| SCHEMBL4070782 | 0.83 | RIPK1 (0.64) | RIPK1POLBKMT2AALDH1A1RAB9A | |
| SCHEMBL4032833 | 0.83 | RIPK1 (0.64) | RIPK1POLBKMT2AALDH1A1RAB9A | |
| SCHEMBL12712926 | 0.82 | NR1H2 (0.53) | RIPK1 | |
| SCHEMBL7133590 | 0.82 | RIPK1 (0.54) | RIPK1KMT2AALDH1A1MEN1 | |
| SCHEMBL25327354 | 0.81 | RIPK1 (0.58) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001831-A2 | COMPOUNDS WHICH INHIBIT THE GLYCINE TRANSPORTER AND USES THEREOF | GLAXO GROUP LIMITED (GB) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007113309-A2 | COMPOUNDS WHICH INHIBIT THE GLYCINE TRANSPORTER AND USES THEREOF | GLAXO GROUP LIMITED (GB) | 2007-10-11 | — | — | WO | disclosed |