Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | DGKA | P23743 | 3/20 | 0.36 |
| ▸ | DGKZ | Q13574 | 3/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7427589 | 1.00 | SIGMAR1 (0.54) | SIGMAR1HRH3DGKADGKZDPP8 | |
| SCHEMBL21831659 | 1.00 | SIGMAR1 (0.54) | SIGMAR1HRH3DGKADGKZDPP8 | |
| SCHEMBL21831126 | 1.00 | SIGMAR1 (0.54) | SIGMAR1HRH3DGKADGKZDPP8 | |
| SCHEMBL7427594 | 1.00 | SIGMAR1 (0.54) | SIGMAR1HRH3DGKADGKZDPP8 | |
| SCHEMBL25327760 | 1.00 | SIGMAR1 (0.54) | SIGMAR1HRH3DGKADGKZDPP8 | |
| SCHEMBL7430109 | 1.00 | SIGMAR1 (0.54) | SIGMAR1HRH3DGKADGKZDPP8 | |
| Hydrochloric Acid SCHEMBL21831397 | 0.98 | SIGMAR1 (0.53) | SIGMAR1HRH3DGKADGKZDPP8 | |
| SCHEMBL21831852 | 0.89 | DGKA (0.46) | SIGMAR1HRH3DGKADGKZOPRD1 | |
| SCHEMBL6495242 | 0.87 | SIGMAR1 (0.54) | SIGMAR1HRH3DGKADGKZ | |
| SCHEMBL26946526 | 0.87 | SIGMAR1 (0.45) | SIGMAR1HRH3DGKADGKZOPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3814348-B9 | SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-11-01 | — | — | EP | disclosed |
| EP-3814348-B1 | SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-08-02 | — | — | EP | disclosed |