Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tetrahydrofuran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.31 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofuran SCHEMBL28302889 | 0.85 | CA1 (0.43) | CA1SMN1; SMN2GAAFFAR3HDAC3 | |
| Tetrahydrofuran SCHEMBL6152903 | 0.84 | CA1 (0.53) | CA1SMN1; SMN2GAAFFAR3HDAC3 | |
| Tetrahydrofuran SCHEMBL28668349 | 0.82 | CA1 (0.45) | CA1SMN1; SMN2GAAALDH1A1 | |
| Tetrahydrofuran SCHEMBL1896714 | 0.82 | ALDH1A1 (0.44) | ALDH1A1POLB | |
| Tetrahydrofuran SCHEMBL8848579 | 0.82 | CA1 (0.50) | CA1SMN1; SMN2GAAFFAR3HDAC3 | |
| Tetrahydrofuran SCHEMBL15993933 | 0.82 | ALDH1A1 (0.50) | ALDH1A1 | |
| Tetrahydrofuran SCHEMBL3369904 | 0.82 | ALDH1A1 (0.50) | ALDH1A1 | |
| Acetic Acid SCHEMBL27362312 | 0.82 | CA1 (0.56) | CA1FFAR3HDAC3HDAC1HDAC2 | |
| Acetic Acid SCHEMBL9319465 | 0.82 | CA1 (0.56) | CA1FFAR3HDAC3HDAC1HDAC2 | |
| Tetrahydrofuran SCHEMBL599386 | 0.80 | ALDH1A1 (0.42) | ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117843711-A | High-performance leaf protein and preparation method thereof | 江南大学 | 2024-04-09 | — | — | CN | disclosed |
| CN-117776899-A | Method for purifying succinic acid from fermentation broth containing magnesium succinate | 淮北创新生物新材料有限责任公司 | 2024-03-29 | — | — | CN | disclosed |
| CN-117305283-A | Mutant for improving arginine deiminase enzyme activity and application thereof | 江南大学 | 2023-12-29 | — | — | CN | disclosed |
| CN-117256759-A | Litsea coreana fermented beverage and preparation method thereof | 山东九赐方生物科技有限公司 | 2023-12-22 | — | — | CN | disclosed |
| CN-116731904-A | Bifidobacterium bifidum resistant to high permeability and application thereof | 江南大学 | 2023-09-12 | — | — | CN | disclosed |
| CN-116590274-A | Method for preparing high F value whey peptide based on magnetic DQTP co-immobilized enzyme and adsorption dearomatization | 江南大学 | 2023-08-15 | — | — | CN | disclosed |
| CN-116530575-A | Method for improving protein digestion performance in food, protein composition and food containing the same | 内蒙古伊利实业集团股份有限公司 | 2023-08-04 | — | — | CN | disclosed |
| WO-2023142838-A1 | METHOD FOR IMPROVING DIGESTION PERFORMANCE FOR PROTEIN IN FOOD, AND PROTEIN COMPOSITION AND FOOD CONTAINING SAME | 内蒙古伊利实业集团股份有限公司 | 2023-08-03 | — | — | WO | disclosed |
| CN-116426419-A | High-permeability-resistant bifidobacterium adolescentis and application thereof | 江南大学 | 2023-07-14 | — | — | CN | disclosed |
| CN-116250570-A | Infant formula milk powder and preparation method thereof | 内蒙古伊利实业集团股份有限公司 | 2023-06-13 | — | — | CN | disclosed |
| CN-112708652-B | Avocado oil-in-water liquid state fermentation product and preparation method and application thereof | 青蛙王子（福建）婴童护理用品有限公司 | 2022-10-21 | — | — | CN | disclosed |
| CN-114903157-A | Tomato concentrated pulp product with low water cooking taste and preparation method thereof | 江南大学 | 2022-08-16 | — | — | CN | disclosed |
| CN-114522183-A | Sea cucumber extract for increasing bone mineral density | 江南大学 | 2022-05-24 | — | — | CN | disclosed |
| CN-111394291-B | Method for producing L-glutamic acid by fermentation of recombinant corynebacterium glutamicum | 江南大学 | 2022-03-15 | — | — | CN | disclosed |
| CN-112080542-B | Preparation method of low phenylalanine egg white protein peptide | 江南大学 | 2022-03-04 | — | — | CN | disclosed |
| CN-112931797-A | Processing method of dry-type cooked beef tenderloin | 江南大学 | 2021-06-11 | — | — | CN | disclosed |
| CN-112708652-A | Avocado oil-in-water liquid state fermentation product and preparation method and application thereof | 青蛙王子（福建）婴童护理用品有限公司 | 2021-04-27 | — | — | CN | disclosed |
| CN-112080542-A | Preparation method of low phenylalanine egg white protein peptide | 江南大学 | 2020-12-15 | — | — | CN | disclosed |
| CN-111838668-A | Highland barley germination method for inhibiting degradation of beta-glucan and enriching GABA | 江南大学 | 2020-10-30 | — | — | CN | disclosed |
| CN-111394291-A | Method for producing L-glutamic acid by utilizing recombinant corynebacterium glutamicum fermentation | 江南大学 | 2020-07-10 | — | — | CN | disclosed |