Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.47 |
| ▸ | MTOR | P42345 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2534195 | 0.87 | PKM (0.56) | PKMPIK3CAMTORLMNATSHR | |
| SCHEMBL2532976 | 0.81 | PIK3CA (0.61) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4455473 | 0.80 | PIK3CA (0.49) | PKMPIK3CAMTORLMNATSHR | |
| SCHEMBL2535375 | 0.79 | PIK3CA (0.56) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL2534318 | 0.77 | MTOR (0.43) | PKMPIK3CAMTORLMNATSHR | |
| SCHEMBL17773015 | 0.71 | LMNA (0.44) | PKMPIK3CAMTORLMNATSHR | |
| SCHEMBL29000061 | 0.70 | PIK3CA (0.64) | PIK3CAMTORALDH1A1NPSR1PIK3CG | |
| SCHEMBL9619266 | 0.70 | LMNA (0.52) | PKMPIK3CAMTORLMNATSHR | |
| SCHEMBL19665253 | 0.69 | LMNA (0.86) | PKMPIK3CAMTORLMNATSHR | |
| SCHEMBL3797375 | 0.68 | PDE4A (0.42) | PIK3CAMTORLMNAHTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8039469-B2 | Triazine compounds as PI3 kinase and mTOR inhibitors | WYETH LLC (US) | 2011-10-18 | — | — | US | disclosed |