Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 3/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 4/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | IGF2BP2 | Q9Y6M1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2535478 | 0.86 | SERPINE1 (0.45) | SLC6A2SLC6A4AURKATPX2EPHX2 | |
| SCHEMBL12225947 | 0.86 | ERN1 (0.56) | ERN1SLC6A2SLC6A4AURKATPX2 | |
| SCHEMBL3863802 | 0.84 | GAA (0.46) | ERN1SLC6A2SLC6A4AURKATPX2 | |
| SCHEMBL3863808 | 0.84 | GAA (0.46) | ERN1SLC6A2SLC6A4AURKATPX2 | |
| SCHEMBL2533346 | 0.82 | ERN1 (0.44) | ERN1SLC6A2SLC6A4AURKATPX2 | |
| SCHEMBL2667009 | 0.79 | NOTUM (0.45) | ERN1SLC6A2SLC6A4AURKATPX2 | |
| SCHEMBL2534779 | 0.77 | PSEN1 (0.53) | ERN1MRGPRX4 | |
| SCHEMBL5094883 | 0.77 | SLC6A2 (0.46) | SLC6A2SLC6A4AURKATPX2FAAH | |
| SCHEMBL14930553 | 0.76 | CA1 (0.58) | AURKATPX2FAAHEPHX2MRGPRX4 | |
| SCHEMBL2532587 | 0.74 | PSEN1 (0.52) | EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8044236-B2 | Inhibitors against plasminogen activator inhibitor-1 (PAI-1); anticoagulants; 2-(aryl or aralkyloxy-)-5-(aryl)phenyl}acetic acid (or derivatives of propionic acid, propenoic acid, N-oxamic acid or 1H-tetrazol-5-yl); occlusion, stenosis; low molecular weight; gene expression inhibition | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2011-10-25 | — | — | US | disclosed |