Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 4/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 5/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.31 |
| ▸ | GYS1 | P13807 | 1/20 | 0.31 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29132485 | 0.94 | CYP2C9 (0.33) | PTGER1CYP2C9RORCKMT2AL3MBTL1 | |
| SCHEMBL25338437 | 0.85 | NFKB1 (0.36) | PTGER1CYP2C9RORCKEAP1NFE2L2 | |
| SCHEMBL25339483 | 0.81 | RORC (0.35) | PTGER1CYP2C9RORCRXRARXRB | |
| SCHEMBL25338866 | 0.81 | PDE4B (0.33) | PTGER1CYP2C9RORCKEAP1NFE2L2 | |
| SCHEMBL25340859 | 0.81 | CYP2C9 (0.34) | PTGER1CYP2C9RORCKEAP1NFE2L2 | |
| SCHEMBL25338244 | 0.81 | KMT2A (0.37) | PTGER1CYP2C9RORCKEAP1NFE2L2 | |
| SCHEMBL25339196 | 0.80 | RORC (0.35) | RORCKEAP1NFE2L2 | |
| SCHEMBL29132487 | 0.80 | NFKB1 (0.35) | PTGER1CYP2C9RORCKMT2AL3MBTL1 | |
| SCHEMBL30683988 | 0.78 | RORC (0.34) | PTGER1CYP2C9RORCKMT2AL3MBTL1 | |
| SCHEMBL29132483 | 0.78 | RORC (0.34) | PTGER1CYP2C9RORCKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4211122-A1 | PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF | Calico Life Sciences LLC (US) | 2023-07-19 | — | — | EP | disclosed |