Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1355773 | 0.82 | ALDH1A1 (0.59) | ALDH1A1HTTRAB9AKDM4ENPSR1 | |
| SCHEMBL25342498 | 0.82 | ALDH1A1 (0.49) | ALDH1A1HTTRAB9AGPR35PAX8 | |
| SCHEMBL22805526 | 0.80 | ALDH1A1 (0.60) | ALDH1A1HTTRAB9AKDM4ENPSR1 | |
| SCHEMBL1354014 | 0.80 | ALDH1A1 (0.66) | ALDH1A1HTTRAB9AKDM4ENPSR1 | |
| SCHEMBL1355251 | 0.79 | ALDH1A1 (0.68) | ALDH1A1HTTRAB9AKDM4ENPSR1 | |
| SCHEMBL174531 | 0.79 | ALDH1A1 (0.59) | ALDH1A1HTTRAB9APAX8KDM4E | |
| SCHEMBL24218363 | 0.79 | ALDH1A1 (0.59) | ALDH1A1HTTRAB9APAX8KDM4E | |
| SCHEMBL17714338 | 0.79 | PAX8 (0.54) | ALDH1A1HTTRAB9APAX8KDM4E | |
| SCHEMBL16252401 | 0.78 | ALDH1A1 (0.48) | ALDH1A1HTTRAB9APAX8KDM4E | |
| SCHEMBL5332408 | 0.75 | ALDH1A1 (0.85) | ALDH1A1HTTRAB9APAX8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4472739-A1 | IMIDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2024-12-11 | — | — | EP | disclosed |
| WO-2023148129-A1 | IMIDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2023-08-10 | — | — | WO | disclosed |