Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 3/20 | 0.54 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.53 |
| ▸ | USP30 | Q70CQ3 | 5/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | APLNR | P35414 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | CKS1B | P61024 | 1/20 | 0.43 |
| ▸ | SKP1 | P63208 | 1/20 | 0.43 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27211057 | 1.00 | HPGDS (0.54) | HPGDSPRMT5USP30PDE4BEGFR | |
| SCHEMBL30473727 | 1.00 | HPGDS (0.54) | HPGDSPRMT5USP30PDE4BEGFR | |
| SCHEMBL30473674 | 0.84 | PIK3CD (0.51) | HPGDSPRMT5PDE4BJAK2 | |
| SCHEMBL25344277 | 0.84 | PIK3CD (0.51) | HPGDSPRMT5PDE4BJAK2 | |
| SCHEMBL27211356 | 0.84 | PIK3CD (0.51) | HPGDSPRMT5PDE4BJAK2 | |
| SCHEMBL29457359 | 0.83 | PRMT5 (0.47) | HPGDSPRMT5USP30PDE4BJAK2 | |
| SCHEMBL27211046 | 0.83 | PRMT5 (0.47) | HPGDSPRMT5USP30PDE4BJAK2 | |
| SCHEMBL25341678 | 0.83 | PRMT5 (0.47) | HPGDSPRMT5USP30PDE4BJAK2 | |
| SCHEMBL25343640 | 0.83 | PDE4B (0.47) | HPGDSPRMT5USP30PDE4BJAK2 | |
| SCHEMBL29457556 | 0.83 | PDE4B (0.47) | HPGDSPRMT5USP30PDE4BJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225746-A1 | MRGX2 ANTAGONISTS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022073904-A1 | MRGX2 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2022-04-14 | — | — | WO | disclosed |