Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.38 |
| ▸ | TP53 | P04637 | 8/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.37 |
| ▸ | SLC2A2 | P11168 | 2/20 | 0.37 |
| ▸ | SLC2A3 | P11169 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25345417 | 0.83 | TP53 (0.38) | MAPTTP53SLC2A1SLC2A2SLC2A3 | |
| SCHEMBL25343558 | 0.82 | GRM1 (0.32) | SMN1; SMN2CYP17A1POLB | |
| SCHEMBL25342542 | 0.79 | TP53 (0.38) | MAPTTP53SLC2A1SLC2A2SLC2A3 | |
| SCHEMBL839701 | 0.79 | CYP17A1 (0.53) | MAPTTP53SLC2A1SLC2A2SLC2A3 | |
| SCHEMBL30568414 | 0.79 | CYP17A1 (0.53) | MAPTTP53SLC2A1SLC2A2SLC2A3 | |
| SCHEMBL839516 | 0.77 | XDH (0.38) | MAPTTP53HPGDSMN1; SMN2KDM4E | |
| SCHEMBL25342907 | 0.77 | CYP17A1 (0.43) | MAPTTP53SLC2A1SLC2A2SLC2A3 | |
| SCHEMBL13387475 | 0.75 | TP53 (0.59) | MAPTTP53HPGDSMN1; SMN2KDM4E | |
| SCHEMBL25344682 | 0.74 | SLC2A1 (0.42) | MAPTTP53SLC2A1SLC2A2SLC2A3 | |
| SCHEMBL25342469 | 0.74 | SLC2A1 (0.43) | MAPTTP53SLC2A1SLC2A2SLC2A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4472739-A1 | IMIDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2024-12-11 | — | — | EP | disclosed |
| WO-2023148129-A1 | IMIDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2023-08-10 | — | — | WO | disclosed |