Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 8/20 | 0.42 |
| ▸ | SLC2A3 | P11169 | 8/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | SLC2A2 | P11168 | 3/20 | 0.41 |
| ▸ | PIP4K2A | P48426 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25342873 | 0.85 | SLC2A1 (0.42) | SLC2A1SLC2A3CYP17A1SLC2A2MAPT | |
| SCHEMBL30568631 | 0.85 | SLC2A1 (0.42) | SLC2A1SLC2A3CYP17A1SLC2A2MAPT | |
| SCHEMBL25342932 | 0.83 | ALDH1A1 (0.34) | SLC2A1SLC2A3CYP17A1SLC2A2MAPT | |
| SCHEMBL25342581 | 0.81 | LMNA (0.40) | SLC2A1SLC2A3CYP17A1MAPTLMNA | |
| SCHEMBL30568665 | 0.81 | LMNA (0.40) | SLC2A1SLC2A3CYP17A1MAPTLMNA | |
| SCHEMBL25342907 | 0.81 | CYP17A1 (0.43) | SLC2A1SLC2A3CYP17A1SLC2A2MAPT | |
| SCHEMBL25344741 | 0.81 | SLC2A1 (0.56) | SLC2A1SLC2A3CYP17A1SLC2A2PIP4K2A | |
| SCHEMBL25344401 | 0.80 | SLC2A1 (0.47) | SLC2A1SLC2A3SLC2A2PIP4K2AMAPT | |
| SCHEMBL25346439 | 0.78 | MAPT (0.32) | CYP17A1MAPTKDM4ENPC1RAB9A | |
| SCHEMBL25342469 | 0.76 | SLC2A1 (0.43) | SLC2A1SLC2A3CYP17A1SLC2A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4739670-A1 | MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2026-05-13 | — | — | EP | disclosed |
| WO-2025012057-A1 | MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2025-01-16 | — | — | WO | disclosed |
| EP-4472739-A1 | IMIDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2024-12-11 | — | — | EP | disclosed |
| WO-2023148129-A1 | IMIDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2023-08-10 | — | — | WO | disclosed |