Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | FPR3 | P25089 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.35 |
| ▸ | STK17B | O94768 | 1/20 | 0.32 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.31 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.31 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.31 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25342497 | 0.85 | METAP2 (0.38) | METAP2FPR3FPR2AAK1STK17B | |
| SCHEMBL5128404 | 0.84 | METAP2 (0.41) | METAP2FPR3FPR2AAK1STK17B | |
| SCHEMBL25344251 | 0.83 | METAP2 (0.36) | METAP2FPR3FPR2CYP1A2DRD2 | |
| SCHEMBL25341607 | 0.82 | METAP2 (0.41) | METAP2FPR3FPR2AAK1CA14 | |
| SCHEMBL25343680 | 0.80 | METAP2 (0.36) | METAP2FPR3FPR2AAK1CA14 | |
| SCHEMBL25346494 | 0.77 | METAP2 (0.36) | METAP2FPR3FPR2AAK1STK17B | |
| SCHEMBL25343192 | 0.76 | AAK1 (0.39) | METAP2FPR3FPR2AAK1CA14 | |
| SCHEMBL25345126 | 0.76 | METAP2 (0.38) | METAP2FPR3FPR2AAK1CA14 | |
| SCHEMBL1979475 | 0.74 | MCHR1 (0.42) | METAP2FPR3FPR2CA14CYP1A2 | |
| SCHEMBL18767671 | 0.72 | METAP2 (0.42) | METAP2FPR3FPR2AAK1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4472739-A1 | IMIDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2024-12-11 | — | — | EP | disclosed |
| WO-2023148129-A1 | IMIDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2023-08-10 | — | — | WO | disclosed |