Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5028697 | 0.86 | MAPT (0.44) | METAP2ALDH1A1MAPTLMNACYP3A4 | |
| SCHEMBL25346494 | 0.84 | METAP2 (0.36) | METAP2ALDH1A1HSP90AA1HPGDMAPT | |
| SCHEMBL31376654 | 0.84 | CHRM2 (0.41) | METAP2ALDH1A1HPGDMAPTNPSR1 | |
| SCHEMBL25344580 | 0.83 | METAP2 (0.38) | METAP2CYP1A2DRD2FPR3FPR2 | |
| SCHEMBL25342692 | 0.82 | MAPT (0.38) | METAP2ALDH1A1HPGDMAPTNPSR1 | |
| SCHEMBL25344845 | 0.79 | ALDH1A1 (0.46) | METAP2ALDH1A1HPGDMAPTLMNA | |
| SCHEMBL25344735 | 0.78 | MEN1 (0.39) | METAP2ALDH1A1MAPTHTTGAA | |
| SCHEMBL25343679 | 0.78 | ALDH1A1 (0.60) | ALDH1A1MAPTNPSR1LMNACYP1A2 | |
| SCHEMBL25342497 | 0.77 | METAP2 (0.38) | METAP2CYP1A2FPR3FPR2 | |
| SCHEMBL25345810 | 0.76 | METAP2 (0.36) | METAP2MAPTCHRM2CHRM1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4472739-A1 | IMIDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2024-12-11 | — | — | EP | disclosed |
| WO-2023148129-A1 | IMIDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2023-08-10 | — | — | WO | disclosed |