Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10696332 | 0.89 | POLB (0.41) | GAAPKMPOLBMEN1KMT2A | |
| SCHEMBL17231387 | 0.76 | MEN1 (0.47) | POLBMEN1KMT2AMAPTPDE4A | |
| SCHEMBL10381827 | 0.73 | PKM (0.51) | GAAPKMPOLBMEN1KMT2A | |
| SCHEMBL3935379 | 0.73 | IP6K1 (0.52) | POLBMEN1KMT2AMAPTPDE4A | |
| SCHEMBL5539734 | 0.72 | MEN1 (0.56) | PKMPOLBMEN1KMT2AMAPT | |
| SCHEMBL2490105 | 0.71 | MPI (0.43) | GAAPKMPOLBMEN1KMT2A | |
| SCHEMBL24201847 | 0.70 | MEN1 (0.50) | GAAPKMPOLBMEN1KMT2A | |
| SCHEMBL9028558 | 0.70 | MEN1 (0.50) | GAAPKMPOLBMEN1KMT2A | |
| SCHEMBL13993447 | 0.70 | MEN1 (0.50) | GAAPKMPOLBMEN1KMT2A | |
| SCHEMBL5539731 | 0.70 | MEN1 (0.50) | GAAPKMPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756112-B1 | PYRROLOBENZIMIDAZOLONES AND THEIR USE AS ANTIPROLIFERATIVE AGENTS | BOEHRINGER INGELHEIM INT (DE) | 2011-10-26 | — | — | EP | disclosed |
| EP-1598353-A1 | Pyrrolobenzimidazolones and their use as antiproliferative agents | Boehringer Ingelheim International GmbH (DE) | 2005-11-23 | — | — | EP | disclosed |
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |