Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VHL | P40337 | 10/20 | 0.58 |
| ▸ | ELOC | Q15369 | 6/20 | 0.40 |
| ▸ | ELOB | Q15370 | 6/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21069600 | 0.83 | VHL (0.82) | VHLELOCELOB | |
| SCHEMBL30519936 | 0.81 | VHL (0.50) | VHLKMT2AMEN1GAA | |
| SCHEMBL23320837 | 0.81 | VHL (0.58) | VHLELOCELOBCYP1A2CYP2D6 | |
| SCHEMBL25348347 | 0.78 | VHL (0.55) | VHLELOCELOBCYP1A2CYP2D6 | |
| SCHEMBL25348301 | 0.75 | VHL (0.51) | VHLELOCELOB | |
| SCHEMBL19088890 | 0.73 | KDM4E (0.55) | KDM4EALDH1A1KMT2A | |
| SCHEMBL21741885 | 0.73 | VHL (1.00) | VHLELOCELOBKDM4EKMT2A | |
| SCHEMBL25346029 | 0.73 | VHL (0.38) | VHLCYP1A2CYP2C9TSHRCYP2C19 | |
| SCHEMBL25346034 | 0.73 | VHL (0.38) | VHLCYP1A2CYP2C9TSHRCYP2C19 | |
| SCHEMBL11533429 | 0.71 | CYP2C9 (0.65) | CYP1A2CYP2D6CYP2C9TSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023152666-A1 | 3-SUBSTITUTED PYRIDAZINE COMPOUNDS AS SMARCA2 AND/OR SMARCA4 DEGRADERS | AURIGENE ONCOLOGY LIMITED (IN) | 2023-08-17 | — | — | WO | disclosed |