Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VHL | P40337 | 14/20 | 0.55 |
| ▸ | ELOC | Q15369 | 8/20 | 0.41 |
| ▸ | ELOB | Q15370 | 8/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30520161 | 0.82 | VHL (0.48) | VHLELOCELOBKMT2AMEN1 | |
| SCHEMBL21069600 | 0.81 | VHL (0.82) | VHLELOCELOB | |
| SCHEMBL23320837 | 0.78 | VHL (0.58) | VHLELOCELOBALDH1A1LMNA | |
| SCHEMBL25348264 | 0.78 | VHL (0.58) | VHLELOCELOBALDH1A1LMNA | |
| SCHEMBL25347318 | 0.75 | VHL (0.37) | VHLALDH1A1KDM4E | |
| SCHEMBL25347321 | 0.75 | VHL (0.37) | VHLALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL25347195 | 0.75 | LOXL2 (0.42) | VHLLMNA | |
| SCHEMBL25348301 | 0.73 | VHL (0.51) | VHLELOCELOB | |
| SCHEMBL21741885 | 0.71 | VHL (1.00) | VHLELOCELOBKMT2AKDM4E | |
| SCHEMBL26497908 | 0.71 | VHL (0.74) | VHLELOCELOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023152666-A1 | 3-SUBSTITUTED PYRIDAZINE COMPOUNDS AS SMARCA2 AND/OR SMARCA4 DEGRADERS | AURIGENE ONCOLOGY LIMITED (IN) | 2023-08-17 | — | — | WO | disclosed |