SCHEMBL25349889

SCHEMBL25349889

Cn1c(=O)c(C#N)c(Cl)c2ccnc(Cl)c21

nearest known ligand 0.42

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ BCL6 P41182 17/20 0.42
▸ KDM4E B2RXH2 1/20 0.39
▸ MEN1 O00255 1/20 0.39
▸ MAPT P10636 1/20 0.39
▸ KMT2A Q03164 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.38
▸ RXFP1 Q9HBX9 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30539750 0.86 BCL6 (0.40) BCL6KDM4EMEN1MAPTKMT2A
SCHEMBL25350245 0.86 BCL6 (0.40) BCL6KDM4EMEN1MAPTKMT2A
SCHEMBL23410196 0.77 PSMB8 (0.43) KDM4EMEN1MAPTKMT2AALDH1A1
SCHEMBL29891599 0.77 PSMB8 (0.43) KDM4EMEN1MAPTKMT2AALDH1A1
SCHEMBL23410174 0.74 ALDH1A1 (0.37) KDM4EMEN1MAPTKMT2AALDH1A1
SCHEMBL29891695 0.74 ALDH1A1 (0.41) KDM4EMEN1MAPTKMT2AALDH1A1
SCHEMBL23410172 0.74 ALDH1A1 (0.41) KDM4EMEN1MAPTKMT2AALDH1A1
SCHEMBL569008 0.70 EGFR (0.55) KDM4EMEN1MAPTKMT2AALDH1A1
SCHEMBL29891965 0.70 EGFR (0.55) KDM4EMEN1MAPTKMT2AALDH1A1
SCHEMBL23293515 0.69 ALDH1A1 (0.42) BCL6KDM4EMEN1MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260124198-A1 ANTIVIRAL PYRAZOLOPYRIDINONE COMPOUNDS GILEAD SCIENCES INC (US) 2026-05-07 — — US disclosed
EP-4479388-A1 ANTIVIRAL NAPHTHYRIDINONE COMPOUNDS Gilead Sciences, Inc. (US) 2024-12-25 — — EP disclosed
WO-2023154905-A1 ANTIVIRAL PYRAZOLOPYRIDINONE COMPOUNDS GILEAD SCIENCES, INC. (US) 2023-08-17 — — WO disclosed
WO-2023154905-A1 ANTIVIRAL PYRAZOLOPYRIDINONE COMPOUNDS GILEAD SCIENCES, INC. (US) 2023-08-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260124198-A1 ANTIVIRAL PYRAZOLOPYRIDINONE COMPOUNDS ZC3HAV1, CCR1, CCR6 BCL6 39/4885KDM4E 427/4885MEN1 3343/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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