Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PREP | P48147 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25352128 | 1.00 | ACE (0.44) | ACEPOLBTDP1L3MBTL1OPRM1 | |
| SCHEMBL5243620 | 0.87 | ACE (0.46) | ACEPOLBTDP1L3MBTL1MEN1 | |
| SCHEMBL3898933 | 0.87 | ACE (0.46) | ACEPOLBTDP1L3MBTL1MEN1 | |
| SCHEMBL17559354 | 0.87 | ACE (0.46) | ACEPOLBTDP1L3MBTL1MEN1 | |
| SCHEMBL3917500 | 0.80 | NAMPT (0.44) | ACEPOLBOPRD1MEN1KMT2A | |
| SCHEMBL30167028 | 0.80 | NAMPT (0.44) | ACEPOLBOPRD1MEN1KMT2A | |
| SCHEMBL3917502 | 0.80 | NAMPT (0.44) | ACEPOLBOPRD1MEN1KMT2A | |
| SCHEMBL30167045 | 0.80 | NAMPT (0.44) | ACEPOLBOPRD1MEN1KMT2A | |
| SCHEMBL8908771 | 0.78 | ACE (0.61) | ACEPOLBTDP1L3MBTL1LMNA | |
| SCHEMBL3840630 | 0.78 | ACE (0.61) | ACEPOLBTDP1L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114728938-B | Tetrahydroisoquinoline spiro compounds as PRMT5 inhibitors | 南京再明医药有限公司 | 2024-05-24 | — | — | CN | disclosed |
| US-20230250108-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AND USE THEREOF | NANJING ZAIMING PHARMACEUTICAL CO., LTD. (CN) | 2023-08-10 | — | — | US | disclosed |
| EP-4174064-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AND USE THEREOF | Jiangsu Simcere Pharmaceutical Co., Ltd. (CN) | 2023-05-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230250108-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AND USE THEREOF | PRMT5, PRMT1, PRMT3 | ACE 2318/4885POLB 3336/4885TDP1 935/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.