Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.46 |
| ▸ | NR1D1 | P20393 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PREP | P48147 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5243620 | 1.00 | ACE (0.46) | ACENR1D1POLBTDP1L3MBTL1 | |
| SCHEMBL17559354 | 1.00 | ACE (0.46) | ACENR1D1POLBTDP1L3MBTL1 | |
| SCHEMBL25352128 | 0.87 | ACE (0.44) | ACEPOLBTDP1L3MBTL1PREP | |
| SCHEMBL25352132 | 0.87 | ACE (0.44) | ACEPOLBTDP1L3MBTL1PREP | |
| SCHEMBL2731236 | 0.81 | POLB (0.41) | POLBTDP1L3MBTL1DRD2 | |
| SCHEMBL18755262 | 0.80 | HTR1A (0.51) | TDP1L3MBTL1PREPMAPTLMNA | |
| SCHEMBL6477421 | 0.80 | DRD3 (0.40) | HTR1ADRD2DRD3 | |
| SCHEMBL17559392 | 0.80 | NAMPT (0.39) | POLB | |
| SCHEMBL7482325 | 0.79 | NPSR1 (0.53) | NR1D1L3MBTL1 | |
| SCHEMBL29959575 | 0.79 | NPSR1 (0.53) | NR1D1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230112832-A1 | Chemokine CXCR4 Receptor Modulators and Uses Related Thereto | UNIV EMORY (US) | 2023-04-13 | — | — | US | disclosed |
| US-20200054623-A1 | Chemokine CXCR4 Receptor Modulators and Uses Related Thereto | EMORY UNIVERSITY | 2020-02-20 | — | — | US | disclosed |
| CN-110545814-A | Chemokine CXCR4 receptor modulators and uses related thereto | UNIV EMORY | 2019-12-06 | — | — | CN | disclosed |
| WO-2018156595-A1 | CHEMOKINE CXCR4 RECEPTOR MODULATORS AND USES RELATED THERETO | EMORY UNIVERSITY (US) | 2018-08-30 | — | — | WO | disclosed |
| US-7569582-B2 | Aminotropane derivatives, preparation thereof and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2009-08-04 | — | — | US | disclosed |
| EP-1773829-B1 | AMINO-TROPANE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2008-12-17 | — | — | EP | disclosed |
| US-20070191361-A1 | AMINOTROPANE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2007-08-16 | — | — | US | disclosed |
| EP-1773829-A1 | AMINO-TROPANE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006021657-A1 | AMINO-TROPANE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2006-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200054623-A1 | Chemokine CXCR4 Receptor Modulators and Uses Related Thereto | CXCR4, CXCL12, CXCR1 | ACE 3431/4885NR1D1 898/4885POLB 3104/4885 |
| US-20070191361-A1 | AMINOTROPANE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | MC5R, TAAR5, MC4R | ACE 1583/4885NR1D1 922/4885POLB 3848/4885 |
| US-20230112832-A1 | Chemokine CXCR4 Receptor Modulators and Uses Related Thereto | CXCR4, CXCL12, CXCR1 | ACE 3431/4885NR1D1 898/4885POLB 3104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.