Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KAT2B | Q92831 | 16/20 | 0.41 |
| ▸ | BPTF | Q12830 | 2/20 | 0.41 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25356829 | 0.89 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2KAT2BBPTF | |
| SCHEMBL25356824 | 0.89 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2KAT2BBPTF | |
| SCHEMBL25994566 | 0.89 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2KAT2BBPTF | |
| SCHEMBL25994523 | 0.85 | NPBWR1 (0.44) | NPC1RAB9ASMN1; SMN2KAT2BBPTF | |
| SCHEMBL25994611 | 0.82 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2KAT2BBPTF | |
| SCHEMBL25355683 | 0.82 | KAT2B (0.42) | NPC1RAB9ASMN1; SMN2KAT2BBPTF | |
| SCHEMBL25994561 | 0.80 | NPBWR1 (0.46) | NPC1RAB9ASMN1; SMN2KAT2BBPTF | |
| SCHEMBL25994560 | 0.80 | NPBWR1 (0.46) | NPC1RAB9ASMN1; SMN2KAT2BBPTF | |
| SCHEMBL26007778 | 0.79 | RAB9A (0.66) | NPC1RAB9ASMN1; SMN2KAT2BBRD9 | |
| SCHEMBL25994521 | 0.78 | RAB9A (0.48) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023122778-A1 | PYRIDAZINONE DERIVATIVES USEFUL AS T CELL ACTIVATORS | GOSSAMER BIO SERVICES, INC. (US) | 2023-06-29 | — | — | WO | disclosed |
| WO-2023122778-A1 | PYRIDAZINONE DERIVATIVES USEFUL AS T CELL ACTIVATORS | GOSSAMER BIO SERVICES, INC. (US) | 2023-06-29 | — | — | WO | disclosed |