Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 4/20 | 0.57 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.32 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.31 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.31 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29494685 | 0.84 | NLRP3 (0.52) | NLRP3PDGFRACDK5TYRO3POLB | |
| SCHEMBL29492185 | 0.84 | NLRP3 (0.64) | NLRP3PDGFRACDK5TYRO3POLB | |
| SCHEMBL25356354 | 0.81 | NLRP3 (0.64) | NLRP3PDGFRACDK5TYRO3POLB | |
| SCHEMBL29494681 | 0.81 | NLRP3 (0.39) | NLRP3PDGFRACDK5TYRO3CHEK1 | |
| SCHEMBL25431544 | 0.79 | NLRP3 (0.59) | NLRP3TYRO3POLBMAPK8LMNA | |
| SCHEMBL25357358 | 0.77 | NLRP3 (0.48) | NLRP3PDGFRACDK5TYRO3CHEK1 | |
| SCHEMBL25360566 | 0.77 | NLRP3 (0.48) | NLRP3PDGFRACDK5TYRO3CHEK1 | |
| SCHEMBL705011 | 0.76 | NLRP3 (0.47) | NLRP3PDGFRACDK5TYRO3POLB | |
| SCHEMBL25357137 | 0.74 | NLRP3 (0.44) | NLRP3PDGFRACDK5TYRO3CHEK1 | |
| SCHEMBL25356370 | 0.73 | NLRP3 (0.53) | NLRP3PDGFRACDK5TYRO3MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4217346-B1 | NEW COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2025-07-02 | — | — | EP | disclosed |
| US-20230391756-A1 | NEW COMPOUND | JANSSEN PHARMACEUTICA NV (BE) | 2023-12-07 | — | — | US | disclosed |
| EP-4217346-A1 | NEW COMPOUNDS | JANSSEN Pharmaceutica NV (BE) | 2023-08-02 | — | — | EP | disclosed |
| CN-116323585-A | New compounds | 詹森药业有限公司 | 2023-06-23 | — | — | CN | disclosed |
| WO-2022063876-A1 | NEW COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2022-03-31 | — | — | WO | disclosed |
| EP-3974415-A1 | NLRP3 MODULATORS | Janssen Pharmaceutica NV (BE) | 2022-03-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230391756-A1 | NEW COMPOUND | NLRP3, NLRP1, IL1R1 | NLRP3 1/4885PDGFRA 4323/4885CDK5 1965/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.