SCHEMBL25358069

SCHEMBL25358069

Cc1ccc(C(NCCCC[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])C(=O)Nc2ccc(CO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)cc2)(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.35

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ SIRT1 Q96EB6 2/20 0.35
▸ SIRT2 Q8IXJ6 1/20 0.35
▸ FOLH1 Q04609 14/20 0.35
▸ SIRT5 Q9NXA8 1/20 0.34
▸ CALCRL Q16602 1/20 0.34
▸ PSMB5 P28074 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25361657 0.93 FOLH1 (0.34) FOLH1PSMB5
SCHEMBL29589609 0.92 SIRT2 (0.34) SIRT1SIRT2SIRT5
SCHEMBL25362982 0.91 FOLH1 (0.38) FOLH1PSMB5
SCHEMBL26015581 0.90 FOLH1 (0.38) SIRT1SIRT2FOLH1SIRT5CALCRL
SCHEMBL25362741 0.89 FOLH1 (0.38) FOLH1CALCRL
SCHEMBL25362754 0.89 FOLH1 (0.38) FOLH1CALCRL
SCHEMBL25361472 0.88 FOLH1 (0.38) FOLH1CALCRL
SCHEMBL25361811 0.88 FOLH1 (0.38) FOLH1CALCRL
SCHEMBL25362331 0.86 FOLH1 (0.38) FOLH1CALCRL
SCHEMBL25362344 0.86 FOLH1 (0.38) FOLH1CALCRL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4237008-A2 CARRIER PARTICLE-DRUG CONJUGATES, SELF-IMMOLATIVE LINKERS, AND USES THEREOF Elucida Oncology, Inc. (US) 2023-09-06 — — EP disclosed
US-20230241243-A1 CARRIER PARTICLE-DRUG CONJUGATES, SELF-IMMOLATIVE LINKERS, AND USES THEREOF ELUCIDA ONCOLOGY, INC. 2023-08-03 — — US disclosed
WO-2022093800-A2 CARRIER PARTICLE-DRUG CONJUGATES, SELF-IMMOLATIVE LINKERS, AND USES THEREOF ELUCIDA ONCOLOGY, INC. (US) 2022-05-05 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230241243-A1 CARRIER PARTICLE-DRUG CONJUGATES, SELF-IMMOLATIVE LINKERS, AND USES THEREOF NDC1, KIFC1, SDCBP SIRT1 2353/4885SIRT2 2798/4885FOLH1 433/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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