SCHEMBL2536058

SCHEMBL2536058

C[SiH](C)[Ti](Cl)(Cl)(C1C=Cc2c(-c3cccc4ccccc34)cccc21)C1C=Cc2c(-c3cccc4ccccc34)cccc21

nearest known ligand 0.31

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.31
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
KDM4E B2RXH2 1/20 0.30
TDP2 O95551 1/20 0.30
ALDH1A1 P00352 1/20 0.30
HPGD P15428 1/20 0.30
ALOX12 P18054 1/20 0.30
MAPK1 P28482 1/20 0.30
CASP3 P42574 1/20 0.30
HTT P42858 1/20 0.30
GALK1 P51570 1/20 0.30
BLM P54132 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30
SENP8 Q96LD8 1/20 0.30
SENP7 Q9BQF6 1/20 0.30
SENP6 Q9GZR1 1/20 0.30
KDM4C Q9H3R0 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7107904 0.79 MAPT (0.34) MAPTNPC1RAB9ASMN1; SMN2KDM4E
Hydrochloric Acid SCHEMBL2536060 0.78 ALOX15 (0.32) MAPTNPC1RAB9ASMN1; SMN2KDM4E
SCHEMBL7638200 0.76 MAPT (0.33) MAPTNPC1RAB9ASMN1; SMN2KDM4E
SCHEMBL8357760 0.75 ENPP3 (0.32) MAPTNPC1RAB9ASMN1; SMN2ALDH1A1
SCHEMBL674147 0.74 MAPT (0.31) MAPTNPC1RAB9ASMN1; SMN2KDM4E
SCHEMBL2534841 0.74 BRD4 (0.33) KDM4E
SCHEMBL8457974 0.73
SCHEMBL8355722 0.73 MAPT (0.34) MAPTNPC1RAB9ASMN1; SMN2KDM4E
SCHEMBL7149985 0.73 MAPT (0.37) MAPTNPC1RAB9ASMN1; SMN2KDM4E
SCHEMBL8357284 0.73 ALOX15 (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8044155-B2 Coordination polymerization catalyst containing magnesium compound, titanium compound and organoaluminum compound STICHTING DUTCH POLYMER INSTITUTE (NL) 2011-10-25 US disclosed
EP-1716185-B1 Titanocene-based catalyst system STICHTING DUTCH POLYMER INST (NL) 2009-10-21 EP disclosed
US-20080234452-A1 TITANOCENE-BASED CATALYST SYSTEM STICHTING DUTCH POLYMER INSTITUTE (NL) 2008-09-25 US disclosed
US-20070179049-A1 Titanocenen-based catalyst system STICHTING DUTCH POLYMER INSTITUTE (NL) 2007-08-02 US disclosed
EP-1716185-A1 TITANOCENE-BASED CATALYST SYSTEM Stichting Dutch Polymer Institute (NL) 2006-11-02 EP disclosed
WO-2005077989-A1 TITANOCENEN-BASED CATALYST SYSTEM STICHTING DUTCH POLYMER INSTITUTE (NL) 2005-08-25 WO disclosed
EP-1564226-A1 Titanocene-based catalyst system Stichting Dutch Polymer Institute (NL) 2005-08-17 EP disclosed