Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | SPR | P35270 | 4/20 | 0.40 |
| ▸ | EED | O75530 | 1/20 | 0.39 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.39 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.39 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.39 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.39 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.38 |
| ▸ | TNKS | O95271 | 2/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25362011 | 1.00 | HPGDS (0.45) | HPGDSMAPTKDM4ETHRBSPR | |
| SCHEMBL16711597 | 0.79 | TNKS (0.53) | TNKSTNKS2PARP1 | |
| SCHEMBL25363012 | 0.75 | HPGDS (0.56) | HPGDSMAPTKDM4ETHRBTNKS | |
| SCHEMBL26025077 | 0.75 | HPGDS (0.56) | HPGDSMAPTKDM4ETHRBTNKS | |
| SCHEMBL29657985 | 0.73 | HPGDS (0.47) | HPGDSMAPTKDM4ETHRBPDE4B | |
| SCHEMBL22701135 | 0.73 | HPGDS (0.47) | HPGDSMAPTKDM4ETHRBPDE4B | |
| SCHEMBL14343366 | 0.73 | HPGDS (0.45) | HPGDSMAPTKDM4ETHRBEED | |
| SCHEMBL2394684 | 0.72 | HPGDS (0.50) | HPGDSMAPTKDM4ETHRBEED | |
| SCHEMBL2280429 | 0.72 | HPGDS (0.50) | HPGDSMAPTKDM4ETHRBEED | |
| SCHEMBL2390420 | 0.72 | HPGDS (0.50) | HPGDSMAPTKDM4ETHRBEED |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4674841-A2 | PHARMACEUTICAL COMPOUND | Duke Street Bio Limited (GB) | 2026-01-07 | — | — | EP | disclosed |
| EP-4444305-A2 | PHARMACEUTICAL COMPOUND | Duke Street Bio Limited (GB) | 2024-10-16 | — | — | EP | disclosed |
| WO-2023156386-A2 | PHARMACEUTICAL COMPOUND | Duke Street Bio Limited (GB) | 2023-08-24 | — | — | WO | disclosed |
| WO-2023156386-A2 | PHARMACEUTICAL COMPOUND | Duke Street Bio Limited (GB) | 2023-08-24 | — | — | WO | disclosed |