Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.48 |
| ▸ | MTOR | P42345 | 3/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2536344 | 0.96 | PIK3CA (0.51) | PTPN11PIK3CAMTORPIK3CGHPGD | |
| SCHEMBL2535018 | 0.82 | PTPN11 (0.53) | PTPN11PIK3CAMTORPIK3CGALDH1A1 | |
| SCHEMBL2533509 | 0.81 | PTPN11 (0.53) | PTPN11PIK3CAMTORPIK3CGALDH1A1 | |
| SCHEMBL2535020 | 0.81 | LMNA (0.47) | PTPN11PIK3CAMTORPIK3CGALDH1A1 | |
| SCHEMBL2533512 | 0.81 | LMNA (0.45) | PTPN11PIK3CAALDH1A1L3MBTL1LMNA | |
| SCHEMBL2535568 | 0.77 | PTPN11 (0.50) | PTPN11PIK3CAMTORPIK3CGALDH1A1 | |
| SCHEMBL2535576 | 0.77 | PKM (0.41) | PTPN11PIK3CAMTORPIK3CGALDH1A1 | |
| SCHEMBL29000061 | 0.76 | PIK3CA (0.64) | PIK3CAMTORPIK3CGALDH1A1L3MBTL1 | |
| SCHEMBL2535323 | 0.76 | PTPN11 (0.49) | PTPN11PIK3CAMTORPIK3CGALDH1A1 | |
| SCHEMBL2535324 | 0.76 | PIK3CA (0.41) | PTPN11PIK3CAMTORPIK3CGALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8039469-B2 | Triazine compounds as PI3 kinase and mTOR inhibitors | WYETH LLC (US) | 2011-10-18 | — | — | US | disclosed |