Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | TEK | Q02763 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.39 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29274955 | 0.84 | KDM4E (0.49) | AURKALCKKDRAURKBRAB9A | |
| SCHEMBL22902414 | 0.83 | MAPT (0.44) | KDM4ELMNAALDH1A1HPGDMEN1 | |
| SCHEMBL29522705 | 0.83 | MAPT (0.44) | KDM4ELMNAALDH1A1HPGDMEN1 | |
| SCHEMBL22902398 | 0.83 | SYK (0.45) | METAURKALCKKDRTEK | |
| SCHEMBL4114974 | 0.67 | CTSD (0.69) | RAB9ALMNANPC1ALDH1A1HPGD | |
| SCHEMBL22902724 | 0.67 | MAPT (0.45) | RAB9AKDM4ELMNANPC1ALDH1A1 | |
| SCHEMBL29522713 | 0.67 | MAPT (0.45) | RAB9AKDM4ELMNANPC1ALDH1A1 | |
| SCHEMBL27747787 | 0.66 | HPGD (0.69) | RAB9AKDM4ELMNANPC1ALDH1A1 | |
| SCHEMBL22902446 | 0.66 | MAPT (0.44) | RAB9AKDM4ELMNANPC1ALDH1A1 | |
| SCHEMBL22902779 | 0.66 | MAPT (0.44) | KDM4ELMNAALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3999508-B1 | TRICYCLIC HETEROARYL COMPOUNDS USEFUL AS IRAK4 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2023-08-30 | — | — | EP | disclosed |