Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22902414 | 1.00 | MAPT (0.44) | MAPTPOLBLMNAKDM4EALDH1A1 | |
| SCHEMBL29274955 | 0.85 | KDM4E (0.49) | KDM4EALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL22902398 | 0.84 | SYK (0.45) | KDM4EALDH1A1HPGDKMT2AHSD17B10 | |
| SCHEMBL25365014 | 0.83 | MET (0.44) | LMNAKDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL29522713 | 0.83 | MAPT (0.45) | MAPTPOLBLMNAKDM4EALDH1A1 | |
| SCHEMBL22902724 | 0.83 | MAPT (0.45) | MAPTPOLBLMNAKDM4EALDH1A1 | |
| SCHEMBL22902779 | 0.82 | MAPT (0.44) | MAPTPOLBLMNAKDM4EALDH1A1 | |
| SCHEMBL29522781 | 0.82 | MAPT (0.44) | MAPTPOLBLMNAKDM4EALDH1A1 | |
| SCHEMBL27244340 | 0.80 | KDM4E (0.50) | MAPTPOLBLMNAKDM4EALDH1A1 | |
| SCHEMBL22902446 | 0.80 | MAPT (0.44) | MAPTPOLBLMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114423757-B | Tricyclic heteroaryl compounds useful as IRAK4 inhibitors | 百时美施贵宝公司 | 2024-07-02 | — | — | CN | disclosed |
| CN-114423757-A | Tricyclic heteroaryl compounds useful as IRAK4 inhibitors | 百时美施贵宝公司 | 2022-04-29 | — | — | CN | disclosed |