SCHEMBL25366293

SCHEMBL25366293

C=C1C[C@@H](CO[Si](C)(C)C(C)(C)C)N(C(=O)O)C1

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FKBP1A P62942 1/20 0.31
TOP2A P11388 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25366297 1.00 FKBP1A (0.31) FKBP1ATOP2A
SCHEMBL2842945 0.87 ALDH1A1 (0.36) FKBP1A
SCHEMBL2842338 0.87 ALDH1A1 (0.36) FKBP1A
SCHEMBL2838596 0.87 ALDH1A1 (0.36) FKBP1A
SCHEMBL27190406 0.85 TOP2A (0.34) FKBP1ATOP2A
SCHEMBL5497614 0.82 CYP19A1 (0.34)
SCHEMBL5497620 0.82 CYP19A1 (0.34)
SCHEMBL4214203 0.81 FKBP1A (0.33) FKBP1ATOP2A
SCHEMBL2957842 0.81 FKBP1A (0.33) FKBP1ATOP2A
SCHEMBL4972513 0.81 FKBP1A (0.33) FKBP1ATOP2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023183405-A2 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS ALEXION PHARMACEUTICALS, INC. (US) 2023-09-28 WO disclosed
EP-4216946-A1 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS Achillion Pharmaceuticals, Inc. (US) 2023-08-02 EP disclosed
CN-116437913-A Pharmaceutical compounds for treating complement-mediated disorders 艾其林医药公司 2023-07-14 CN disclosed