Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 18/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.75 |
| ▸ | AXL | P30530 | 12/20 | 0.72 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.65 |
| ▸ | MST1R | Q04912 | 2/20 | 0.65 |
| ▸ | KDR | P35968 | 2/20 | 0.64 |
| ▸ | MERTK | Q12866 | 2/20 | 0.63 |
| ▸ | PLK4 | O00444 | 1/20 | 0.63 |
| ▸ | ABL1 | P00519 | 1/20 | 0.63 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.63 |
| ▸ | LCK | P06239 | 1/20 | 0.63 |
| ▸ | RET | P07949 | 1/20 | 0.63 |
| ▸ | KIT | P10721 | 1/20 | 0.63 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.63 |
| ▸ | PRKACA | P17612 | 1/20 | 0.63 |
| ▸ | FLT3 | P36888 | 1/20 | 0.63 |
| ▸ | ABL2 | P42684 | 1/20 | 0.63 |
| ▸ | FRK | P42685 | 1/20 | 0.63 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25367697 | 0.91 | AXL (0.66) | METCYP3A4CYP2C9AXLTYRO3 | |
| SCHEMBL26033949 | 0.90 | AXL (0.67) | METAXLTYRO3MERTK | |
| SCHEMBL25364883 | 0.90 | AXL (0.67) | METCYP3A4CYP2C9AXLTYRO3 | |
| SCHEMBL26033147 | 0.88 | MET (0.76) | METCYP3A4CYP2C9AXLTYRO3 | |
| SCHEMBL26034086 | 0.88 | MET (0.70) | METCYP3A4CYP2C9AXLTYRO3 | |
| SCHEMBL23999234 | 0.86 | MET (1.00) | METCYP3A4CYP2C9AXLTYRO3 | |
| SCHEMBL29139266 | 0.86 | MET (0.78) | METCYP3A4CYP2C9AXLTYRO3 | |
| SCHEMBL24878515 | 0.85 | AXL (0.76) | METAXLTYRO3MERTK | |
| SCHEMBL26033156 | 0.85 | MET (0.71) | METCYP3A4CYP2C9AXLTYRO3 | |
| SCHEMBL30153731 | 0.84 | MET (0.65) | METCYP3A4CYP2C9AXLTYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023156864-A1 | PYRIDAZINONE-BASED COMPOUNDS AS AXL, C-MET, AND MER INHIBITORS AND METHODS OF USE THEREOF | CMG PHARMACEUTICAL CO., LTD. (KR) | 2023-08-24 | — | — | WO | disclosed |
| WO-2023156864-A1 | PYRIDAZINONE-BASED COMPOUNDS AS AXL, C-MET, AND MER INHIBITORS AND METHODS OF USE THEREOF | CMG PHARMACEUTICAL CO., LTD. (KR) | 2023-08-24 | — | — | WO | disclosed |
| US-20230257364-A1 | PYRIDAZINONE-BASED COMPOUNDS AS AXL, C-MET, AND MER INHIBITORS AND METHODS OF USE THEREOF | CMG PHARMACEUTICAL CO., LTD. (KR) | 2023-08-17 | — | — | US | disclosed |
| US-20230257364-A1 | PYRIDAZINONE-BASED COMPOUNDS AS AXL, C-MET, AND MER INHIBITORS AND METHODS OF USE THEREOF | CMG PHARMACEUTICAL CO., LTD. (KR) | 2023-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230257364-A1 | PYRIDAZINONE-BASED COMPOUNDS AS AXL, C-MET, AND MER INHIBITORS AND METHODS OF USE THEREOF | MERTK, MET, AXL | MET 2/4885CYP3A4 2926/4885CYP2C9 3090/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.