Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1883218 | 0.87 | HPGDS (0.48) | KMT2APOLBMAPTSMN1; SMN2KDM4E | |
| SCHEMBL22902557 | 0.85 | MEN1 (0.47) | MEN1KMT2APOLBMAPTLMNA | |
| SCHEMBL26617853 | 0.83 | TSHR (0.46) | MEN1KMT2AMAPTLMNASMN1; SMN2 | |
| SCHEMBL22902660 | 0.81 | MAPT (0.47) | MEN1KMT2APOLBMAPTLMNA | |
| SCHEMBL4714235 | 0.79 | CNR2 (0.49) | MEN1KMT2APOLBLMNAKDM4E | |
| SCHEMBL12014805 | 0.77 | NQO2 (0.51) | MEN1KMT2APOLBMAPTLMNA | |
| SCHEMBL2203793 | 0.77 | ALDH1A1 (0.54) | MEN1KMT2AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL30923332 | 0.77 | ALDH1A1 (0.54) | MEN1KMT2AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL29799082 | 0.76 | KDM4E (0.54) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL28590535 | 0.76 | KDM4E (0.54) | MEN1KMT2AMAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114423757-B | Tricyclic heteroaryl compounds useful as IRAK4 inhibitors | 百时美施贵宝公司 | 2024-07-02 | — | — | CN | disclosed |
| EP-3999508-B1 | TRICYCLIC HETEROARYL COMPOUNDS USEFUL AS IRAK4 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2023-08-30 | — | — | EP | disclosed |
| CN-114423757-A | Tricyclic heteroaryl compounds useful as IRAK4 inhibitors | 百时美施贵宝公司 | 2022-04-29 | — | — | CN | disclosed |