Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.47 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.41 |
| ▸ | OGA | O60502 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30557399 | 1.00 | MAP4K1 (0.47) | MAP4K1TRPV4OGAGPR119FYN | |
| SCHEMBL25363887 | 0.87 | MAP4K1 (0.52) | MAP4K1OGAGPR119FYNJAK2 | |
| SCHEMBL30899925 | 0.84 | TRPV4 (0.41) | MAP4K1TRPV4OGAGPR119FYN | |
| SCHEMBL30557554 | 0.83 | FYN (0.49) | MAP4K1FYNACVR1 | |
| SCHEMBL25364791 | 0.83 | FYN (0.49) | MAP4K1FYNACVR1 | |
| SCHEMBL25365448 | 0.78 | HRH3 (0.43) | TRPV4OGAGPR119JAK2JAK1 | |
| SCHEMBL25363259 | 0.76 | GPR119 (0.41) | TRPV4GPR119JAK2JAK1TYK2 | |
| SCHEMBL30360601 | 0.76 | MAP4K1 (0.47) | MAP4K1OGAGPR119FYNJAK2 | |
| SCHEMBL26516557 | 0.76 | MAP4K1 (0.47) | MAP4K1OGAGPR119FYNJAK2 | |
| SCHEMBL25362526 | 0.74 | GPR119 (0.44) | TRPV4GPR119JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023159154-A1 | SUBSTITUTED IMIDAZOPYRIDINYL COMPOUNDS USEFUL AS INHIBITORS OF TLR9 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-08-24 | — | — | WO | disclosed |