Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.62 |
| ▸ | NPC1 | O15118 | 4/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 10/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.61 |
| ▸ | MEN1 | O00255 | 5/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25367390 | 1.00 | HCAR3 (0.64) | HCAR3ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL26914018 | 0.90 | MAPT (0.60) | HCAR3ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL26914012 | 0.90 | MAPT (0.60) | HCAR3ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4966338 | 0.89 | HCAR3 (0.54) | HCAR3ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4966333 | 0.89 | HCAR3 (0.54) | HCAR3ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3922767 | 0.86 | HCAR3 (0.50) | HCAR3ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3922764 | 0.86 | HCAR3 (0.50) | HCAR3ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30537061 | 0.84 | MAPT (0.56) | HCAR3ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29052937 | 0.84 | MAPT (0.56) | HCAR3ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29052936 | 0.84 | MAPT (0.56) | HCAR3ALDH1A1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240083886-A1 | HETEROCYCLIC GLP-1 AGONISTS | GASHERBRUM BIO, INC. | 2024-03-14 | — | — | US | disclosed |
| WO-2023164358-A1 | GLP-1R MODULATING COMPOUNDS | ASCLETIS BIOSCIENCE CO., LTD. (CN) | 2023-08-31 | — | — | WO | disclosed |
| US-20230271949-A1 | GLP-1R MODULATING COMPOUNDS | ASCLETIS BIOSCIENCE CO., LTD. (CN) | 2023-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230271949-A1 | GLP-1R MODULATING COMPOUNDS | GLP1R, GIPR, GPR119 | HCAR3 230/4885ALDH1A1 3386/4885NPC1 1714/4885 |
| US-20240083886-A1 | HETEROCYCLIC GLP-1 AGONISTS | GLP1R, GIPR, GCGR | HCAR3 310/4885ALDH1A1 1011/4885NPC1 1291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.