Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | SCD | O00767 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2535885 | 0.86 | PDE2A (0.39) | MAPTTDP1KDM4EKMT2AALDH1A1 | |
| SCHEMBL2536267 | 0.86 | MAPT (0.41) | MAPTCASP3SENP8SENP7SENP6 | |
| SCHEMBL8284695 | 0.81 | KDM4E (0.46) | RAB9AKDM4EKMT2AALDH1A1HPGD | |
| Acetic Acid SCHEMBL2541944 | 0.80 | ACSS2 (0.37) | MAPTSMN1; SMN2NPC1RAB9AASAH1 | |
| SCHEMBL12226831 | 0.80 | SOS1 (0.35) | MAPTSMN1; SMN2TDP1KDM4EKMT2A | |
| SCHEMBL2534604 | 0.80 | TLR8 (0.36) | MAPTASAH1KDM4EKMT2AALDH1A1 | |
| SCHEMBL8241914 | 0.80 | SOS1 (0.43) | RAB9AKDM4EKMT2AALDH1A1L3MBTL1 | |
| SCHEMBL1238613 | 0.79 | KCNH2 (0.43) | MAPTCASP3SENP8SENP7SENP6 | |
| SCHEMBL8284674 | 0.79 | SOS1 (0.42) | MAPTRAB9ATDP1KDM4EKMT2A | |
| SCHEMBL12226826 | 0.79 | KMT2A (0.34) | MAPTTDP1KDM4EKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8044073-B2 | Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus replication | TIBOTEC PHARMACEUTICALS (IE) | 2011-10-25 | — | — | US | disclosed |
| EP-1697343-B1 | AMINOBENZIMIDAZOLES AND BENZIMIDAZOLES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION | TIBOTEC PHARM LTD (IE) | 2009-07-01 | — | — | EP | disclosed |