Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | GFER | P55789 | 2/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD1 | P21728 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | DRD5 | P21918 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8284672 | 0.93 | SOS1 (0.41) | SOS1KDM4EALDH1A1GFERTNF | |
| SCHEMBL8284695 | 0.88 | KDM4E (0.46) | SOS1KDM4EALDH1A1GFERTNF | |
| SCHEMBL8241914 | 0.87 | SOS1 (0.43) | SOS1KDM4EALDH1A1GFERTNF | |
| SCHEMBL12226842 | 0.87 | KDM4E (0.38) | SOS1KDM4EALDH1A1GFERTNF | |
| SCHEMBL8284602 | 0.80 | KDM4E (0.38) | SOS1KDM4EALDH1A1GFERTNF | |
| SCHEMBL8284698 | 0.80 | CDK1 (0.42) | KDM4EALDH1A1KMT2AHSD17B10MAPT | |
| Hydrochloric Acid SCHEMBL2539558 | 0.79 | SOS1 (0.36) | SOS1KDM4EALDH1A1GFERTNF | |
| SCHEMBL8284697 | 0.79 | KDM4E (0.46) | SOS1KDM4EALDH1A1GFERTNF | |
| SCHEMBL2537168 | 0.79 | MAPT (0.46) | SOS1KDM4EALDH1A1GFERTNF | |
| SCHEMBL8284670 | 0.79 | KDM4E (0.37) | SOS1KDM4EALDH1A1GFERTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697343-B1 | AMINOBENZIMIDAZOLES AND BENZIMIDAZOLES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION | TIBOTEC PHARM LTD (IE) | 2009-07-01 | — | — | EP | disclosed |
| WO-2005058869-A1 | AMINOBENZIMIDAZOLES AND BENZIMIDAZOLES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2005-06-30 | — | — | WO | disclosed |