Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.56 |
| ▸ | FAAH | O00519 | 8/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | GPR18 | Q14330 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25372345 | 1.00 | PTPN1 (0.56) | PTPN1FAAHMEN1KMT2ARECQL | |
| SCHEMBL25374908 | 1.00 | PTPN1 (0.56) | PTPN1FAAHMEN1KMT2ARECQL | |
| SCHEMBL16384730 | 0.93 | PTPN1 (0.49) | PTPN1FAAHMEN1KMT2ARECQL | |
| SCHEMBL30838578 | 0.91 | PTPN1 (0.63) | PTPN1FAAHMEN1KMT2ARECQL | |
| SCHEMBL10056657 | 0.91 | PTPN1 (0.63) | PTPN1FAAHMEN1KMT2ARECQL | |
| SCHEMBL30838582 | 0.91 | PTPN1 (0.63) | PTPN1FAAHMEN1KMT2ARECQL | |
| SCHEMBL8750020 | 0.91 | PTPN1 (0.63) | PTPN1FAAHMEN1KMT2ARECQL | |
| SCHEMBL8505361 | 0.91 | PTPN1 (0.63) | PTPN1FAAHMEN1KMT2ARECQL | |
| SCHEMBL31336114 | 0.91 | PTPN1 (0.63) | PTPN1FAAHMEN1KMT2ARECQL | |
| SCHEMBL2810350 | 0.91 | PTPN1 (0.63) | PTPN1FAAHMEN1KMT2ARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4238966-B1 | TETRAHYDRONAPHTHALENE COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF | GUANGZHOU HENOVCOM BIOSCIENCE CO LTD (CN) | 2026-03-11 | — | — | EP | disclosed |
| US-12497378-B2 | Tetrahydronaphthalene compounds, pharmaceutical compositions, and uses thereof | GUANGZHOU HENOVCOM BIOSCIENCE CO., LTD. (CN) | 2025-12-16 | — | — | US | disclosed |
| US-20230391744-A1 | TETRAHYDRONAPHTHALENE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | GUANGZHOU HENOVCOM BIOSCIENCE CO., LTD. (CN) | 2023-12-07 | — | — | US | disclosed |
| EP-4238966-A1 | TETRAHYDRONAPHTHALENE COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF | Guangzhou Henovcom Bioscience Co. Ltd. (CN) | 2023-09-06 | — | — | EP | disclosed |
| CN-114478476-B | Tetrahydronaphthalene compounds, pharmaceutical composition and application thereof | 广州市恒诺康医药科技有限公司 | 2023-06-27 | — | — | CN | disclosed |
| CN-114478476-A | Tetrahydronaphthalenes compounds, pharmaceutical compositions and uses thereof | 广州市恒诺康医药科技有限公司 | 2022-05-13 | — | — | CN | disclosed |
| WO-2022089408-A1 | TETRAHYDRONAPHTHALENE COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF | 广州市恒诺康医药科技有限公司 | 2022-05-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230391744-A1 | TETRAHYDRONAPHTHALENE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | CYP11B2, HTT, REN | PTPN1 1448/4885FAAH 157/4885MEN1 177/4885 |
| US-12497378-B2 | Tetrahydronaphthalene compounds, pharmaceutical compositions, and uses thereof | CYP11B2, HTT, REN | PTPN1 1448/4885FAAH 157/4885MEN1 177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.