Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 3/20 | 0.36 |
| ▸ | AR | P10275 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 9/20 | 0.35 |
| ▸ | NPC1 | O15118 | 8/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL251153 | 0.85 | JAK1 (0.44) | METPDE3BPDE3AJAK1JAK2 | |
| SCHEMBL253774 | 0.84 | CSNK1D (0.41) | ARRAB9ANPC1SMN1; SMN2MAPK1 | |
| SCHEMBL252421 | 0.79 | KDM4E (0.39) | MAPTJAK1JAK2HSD17B10GSK3B | |
| SCHEMBL253536 | 0.77 | USP30 (0.41) | JAK1JAK2GSK3B | |
| SCHEMBL253141 | 0.77 | KDR (0.43) | METPDE3BPDE3AJAK1JAK2 | |
| SCHEMBL251978 | 0.75 | ABL1 (0.36) | METPDE3BPDE3AJAK1 | |
| SCHEMBL251154 | 0.70 | JAK1 (0.49) | METPDE3BPDE3AJAK1JAK2 | |
| SCHEMBL5955578 | 0.69 | JAK1 (0.43) | METMAPTPDE3BPDE3AJAK1 | |
| SCHEMBL5955517 | 0.67 | CSNK1D (0.43) | GSK3B | |
| SCHEMBL5954413 | 0.67 | CSNK1D (0.42) | METJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588107-A1 | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET | Takeda Pharmaceutical Company Limited (JP) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003338-A1 | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-01-05 | — | — | WO | disclosed |