Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | MET | P08581 | 2/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | SLC5A1 | P13866 | 10/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 3/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL253536 | 0.85 | USP30 (0.41) | ABL1SYKJAK1 | |
| SCHEMBL251980 | 0.83 | KDR (0.41) | ABL1JAK1KDR | |
| SCHEMBL253141 | 0.80 | KDR (0.43) | ABL1METPDE3BPDE3AJAK1 | |
| SCHEMBL252421 | 0.80 | KDM4E (0.39) | SYKJAK1KDR | |
| SCHEMBL251153 | 0.79 | JAK1 (0.44) | METPDE3BPDE3AJAK1 | |
| SCHEMBL253773 | 0.75 | MET (0.36) | METPDE3BPDE3AJAK1 | |
| SCHEMBL253289 | 0.69 | MAPK14 (0.40) | SYK | |
| SCHEMBL2747202 | 0.69 | KDR (0.47) | KDR | |
| SCHEMBL2748206 | 0.68 | MET (0.47) | METPDE3BPDE3AKDR | |
| SCHEMBL252772 | 0.68 | GRK5 (0.38) | ABL1SYKJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588107-A1 | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET | Takeda Pharmaceutical Company Limited (JP) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003338-A1 | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-01-05 | — | — | WO | disclosed |