Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 10/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | WNT1 | P04628 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL252421 | 0.88 | KDM4E (0.39) | KDRJAK1JAK2KDM4EHSD17B10 | |
| SCHEMBL251153 | 0.84 | JAK1 (0.44) | JAK1JAK2METPDE3BPDE3A | |
| SCHEMBL253143 | 0.82 | KDR (0.46) | KDRJAK1ABL1JAK2MET | |
| SCHEMBL253536 | 0.82 | USP30 (0.41) | JAK1ABL1JAK2KDM4EPIK3CD | |
| SCHEMBL251978 | 0.80 | ABL1 (0.36) | KDRJAK1ABL1METPDE3B | |
| SCHEMBL253773 | 0.77 | MET (0.36) | JAK1JAK2METPDE3BPDE3A | |
| SCHEMBL5955486 | 0.76 | KDR (0.43) | KDRJAK1ABL1METKIT | |
| SCHEMBL252762 | 0.73 | JAK1 (0.39) | KDRJAK1ABL1JAK2MET | |
| SCHEMBL5955590 | 0.73 | CSNK1D (0.42) | KDRJAK1JAK2METGSK3B | |
| SCHEMBL252805 | 0.71 | KDM4E (0.40) | JAK1ABL1METKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588107-A1 | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET | Takeda Pharmaceutical Company Limited (JP) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003338-A1 | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-01-05 | — | — | WO | disclosed |