Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 8/20 | 0.37 |
| ▸ | CDC25B | P30305 | 8/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.37 |
| ▸ | PTPN6 | P29350 | 4/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 4/20 | 0.37 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.37 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.37 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.37 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.37 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.37 |
| ▸ | NT5E | P21589 | 1/20 | 0.36 |
| ▸ | GJB2 | P29033 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17106846 | 1.00 | PDE2A (0.44) | PDE2AHTR1AHSPA5CA1CA2 | |
| SCHEMBL20434839 | 1.00 | PDE2A (0.44) | PDE2AHTR1AHSPA5CA1CA2 | |
| SCHEMBL17106844 | 1.00 | PDE2A (0.44) | PDE2AHTR1AHSPA5CA1CA2 | |
| SCHEMBL18490316 | 1.00 | PDE2A (0.44) | PDE2AHTR1AHSPA5CA1CA2 | |
| SCHEMBL18787319 | 0.92 | PDE2A (0.50) | PDE2AHTR1AHSPA5CA1CA2 | |
| SCHEMBL17106843 | 0.86 | HTR1A (0.41) | PDE2AHTR1AHSPA5CA1CA2 | |
| SCHEMBL17106842 | 0.86 | HTR1A (0.41) | PDE2AHTR1AHSPA5CA1CA2 | |
| SCHEMBL17106818 | 0.85 | HTR1A (0.43) | PDE2AHTR1AHSPA5CA1CA2 | |
| SCHEMBL25598746 | 0.85 | HTR1A (0.43) | PDE2AHTR1AHSPA5CA1CA2 | |
| SCHEMBL17106820 | 0.85 | HTR1A (0.43) | PDE2AHTR1AHSPA5CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3334745-B1 | CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME LLC (US) | 2024-05-15 | — | — | EP | disclosed |
| EP-3621624-B1 | CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME LLC (US) | 2023-08-30 | — | — | EP | disclosed |