Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HSPA5 | P11021 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.35 |
| ▸ | CDC25B | P30305 | 6/20 | 0.35 |
| ▸ | GJB2 | P29033 | 2/20 | 0.35 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.34 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.34 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.34 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.34 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.34 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.34 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.34 |
| ▸ | NT5E | P21589 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25379329 | 0.92 | PDE2A (0.44) | PDE2AHTR1AHSPA5CA1CA2 | |
| SCHEMBL17106844 | 0.92 | PDE2A (0.44) | PDE2AHTR1AHSPA5CA1CA2 | |
| SCHEMBL18490316 | 0.92 | PDE2A (0.44) | PDE2AHTR1AHSPA5CA1CA2 | |
| SCHEMBL20434839 | 0.92 | PDE2A (0.44) | PDE2AHTR1AHSPA5CA1CA2 | |
| SCHEMBL17106846 | 0.92 | PDE2A (0.44) | PDE2AHTR1AHSPA5CA1CA2 | |
| SCHEMBL29397234 | 0.87 | PDE2A (0.43) | PDE2AHTR1AHSPA5CA1CA2 | |
| SCHEMBL24557909 | 0.87 | PDE2A (0.43) | PDE2AHTR1AHSPA5CA1CA2 | |
| SCHEMBL18787315 | 0.87 | PDE2A (0.52) | PDE2AHTR1AHSPA5CA1CA2 | |
| SCHEMBL22569895 | 0.86 | PDE2A (0.42) | PDE2AHTR1ACA1CA2CA9 | |
| SCHEMBL29397763 | 0.86 | PDE2A (0.42) | PDE2AHTR1ACA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11787832-B2 | 2′-substituted carba-nucleoside analogs for antiviral treatment | GILEAD SCIENCES, INC. (US) | 2023-10-17 | — | — | US | disclosed |
| US-20210253622-A1 | 2'- SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | GILEAD SCIENCES, INC. | 2021-08-19 | — | — | US | disclosed |
| US-10941177-B2 | 2′-substituted carba-nucleoside analogs for antiviral treatment | GILEAD SCIENCES, INC. (US) | 2021-03-09 | — | — | US | disclosed |
| US-20190016749-A1 | 2'-SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | GILEAD SCIENCES, INC. | 2019-01-17 | — | — | US | disclosed |
| US-20170114086-A1 | 2'- SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | GILEAD SCIENCES, INC. | 2017-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210253622-A1 | 2'- SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | PNP, SLC29A1, RNMT | PDE2A 507/4885HTR1A 1362/4885HSPA5 4595/4885 |
| US-20190016749-A1 | 2'-SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | PNP, SLC29A1, RNMT | PDE2A 507/4885HTR1A 1362/4885HSPA5 4595/4885 |
| US-20170114086-A1 | 2'- SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | PNP, SLC29A1, RNMT | PDE2A 507/4885HTR1A 1362/4885HSPA5 4595/4885 |
| US-11787832-B2 | 2′-substituted carba-nucleoside analogs for antiviral treatment | PNP, RNMT, SLC29A1 | PDE2A 491/4885HTR1A 1442/4885HSPA5 4575/4885 |
| US-10941177-B2 | 2′-substituted carba-nucleoside analogs for antiviral treatment | PNP, RNMT, SLC29A1 | PDE2A 491/4885HTR1A 1442/4885HSPA5 4575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.