Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 2/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31263878 | 1.00 | PNMT (0.53) | PNMTOPRM1OPRL1SIGMAR1CYP2D6 | |
| SCHEMBL16411419 | 0.85 | PNMT (0.50) | PNMTOPRM1OPRL1SIGMAR1KCNH2 | |
| SCHEMBL17782500 | 0.84 | OPRM1 (0.61) | PNMTOPRM1OPRL1KCNH2 | |
| SCHEMBL30581918 | 0.84 | OPRM1 (0.61) | PNMTOPRM1OPRL1KCNH2 | |
| Hydrochloric Acid SCHEMBL29590128 | 0.84 | PNMT (0.49) | PNMTOPRM1OPRL1SIGMAR1KCNH2 | |
| Hydrochloric Acid SCHEMBL29589743 | 0.84 | PNMT (0.49) | PNMTOPRM1OPRL1SIGMAR1KCNH2 | |
| Hydrochloric Acid SCHEMBL16416904 | 0.84 | PNMT (0.49) | PNMTOPRM1OPRL1SIGMAR1KCNH2 | |
| Hydrochloric Acid SCHEMBL16417111 | 0.84 | PNMT (0.49) | PNMTOPRM1OPRL1SIGMAR1KCNH2 | |
| Hydrochloric Acid SCHEMBL16415493 | 0.84 | PNMT (0.49) | PNMTOPRM1OPRL1SIGMAR1KCNH2 | |
| Hydrochloric Acid SCHEMBL31263938 | 0.83 | OPRM1 (0.60) | PNMTOPRM1OPRL1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4482832-A1 | 5-[7-(3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBONYL)-1,2,3,4 TETRAHYDROISOQUINOLIN-6-Y L]-1H-PYRROLE-3-CARBOXAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS PRO-APOPTOTIC AGENTS | Les Laboratoires Servier (FR) | 2025-01-01 | — | — | EP | disclosed |
| WO-2023161317-A1 | 5-[7-(3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBONYL)-1,2,3,4 TETRAHYDROISOQUINOLIN-6-Y L]-1H-PYRROLE-3-CARBOXAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS PRO-APOPTOTIC AGENTS | LES LABORATOIRES SERVIER (FR) | 2023-08-31 | — | — | WO | disclosed |