Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | KDM1A | O60341 | 2/20 | 0.52 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25379898 | 1.00 | KDM4E (0.58) | KDM4EALDH1A1HTTMEN1KMT2A | |
| SCHEMBL25376716 | 1.00 | KDM4E (0.58) | KDM4EALDH1A1HTTMEN1KMT2A | |
| SCHEMBL25381009 | 1.00 | KDM4E (0.58) | KDM4EALDH1A1HTTMEN1KMT2A | |
| SCHEMBL30581971 | 0.88 | KDM4E (0.64) | KDM4EALDH1A1HTTMEN1KMT2A | |
| SCHEMBL25379822 | 0.88 | KDM4E (0.64) | KDM4EALDH1A1HTTMEN1KMT2A | |
| SCHEMBL25379818 | 0.88 | KDM4E (0.64) | KDM4EALDH1A1HTTMEN1KMT2A | |
| SCHEMBL25378441 | 0.86 | LTA4H (0.51) | KDM4EALDH1A1HTTMEN1KMT2A | |
| SCHEMBL25376166 | 0.86 | LTA4H (0.51) | KDM4EALDH1A1HTTMEN1KMT2A | |
| SCHEMBL25940273 | 0.81 | LTA4H (0.62) | KDM4EHTTKDM1ALTA4HPOLB | |
| SCHEMBL7400266 | 0.80 | GAA (0.62) | KDM4EALDH1A1KDM1ALTA4HPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4482832-A1 | 5-[7-(3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBONYL)-1,2,3,4 TETRAHYDROISOQUINOLIN-6-Y L]-1H-PYRROLE-3-CARBOXAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS PRO-APOPTOTIC AGENTS | Les Laboratoires Servier (FR) | 2025-01-01 | — | — | EP | disclosed |
| WO-2023161317-A1 | 5-[7-(3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBONYL)-1,2,3,4 TETRAHYDROISOQUINOLIN-6-Y L]-1H-PYRROLE-3-CARBOXAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS PRO-APOPTOTIC AGENTS | LES LABORATOIRES SERVIER (FR) | 2023-08-31 | — | — | WO | disclosed |