SCHEMBL25387486

SCHEMBL25387486

CC(=O)OC1CC(Oc2cc(NC3CCC3)ncn2)CC1N1CCc2ccccc2C1

nearest known ligand 0.41

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ PRMT5 O14744 19/20 0.41
▸ WDR77 Q9BQA1 18/20 0.41
▸ NAE1 Q13564 1/20 0.40
▸ UBA3 Q8TBC4 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26250482 1.00 PRMT5 (0.41) PRMT5WDR77NAE1UBA3
SCHEMBL25388262 0.86 PRMT5 (0.48) PRMT5WDR77
SCHEMBL30493033 0.86 PRMT5 (0.48) PRMT5WDR77
SCHEMBL25387099 0.85 NAE1 (0.48) PRMT5WDR77NAE1UBA3
SCHEMBL26250382 0.85 NAE1 (0.48) PRMT5WDR77NAE1UBA3
SCHEMBL25387881 0.82 PRMT5 (0.56) PRMT5WDR77NAE1UBA3
SCHEMBL31153390 0.82 PRMT5 (0.56) PRMT5WDR77NAE1UBA3
SCHEMBL26247973 0.82 PRMT5 (0.56) PRMT5WDR77NAE1UBA3
SCHEMBL30493058 0.80 GPR119 (0.36) PRMT5WDR77NAE1UBA3
SCHEMBL25387758 0.80 GPR119 (0.36) PRMT5WDR77NAE1UBA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240336593-A1 Compound Having Antitumor Activity And Use Thereof INNOVSTONE THERAPEUTICS LIMITED (CN) 2024-10-10 — — US disclosed
EP-4209485-A1 COMPOUND HAVING ANTITUMOR ACTIVITY AND USE THEREOF Innovstone Therapeutics Limited (CN) 2023-07-12 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240336593-A1 Compound Having Antitumor Activity And Use Thereof PRMT5, PRMT1, PRMT6 PRMT5 1/4885WDR77 157/4885NAE1 1647/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback